Drug

Side-effects

Carboplatin

Cortical blindness, peripheral sensory neuropathy, nausea, vomiting, constipation and diarrhoea.

Cisplatin

Encephalopathy, headache, stroke, seizures, sensory peripheral neuropathy, Lhermitte’s sign, muscle cramps, nausea, vomiting and diarrhoea.

Oxaliplatin

Paraesthesia, sensory peripheral neuropathy, nausea, vomiting, weight loss, constipation and diarrhoea.

5-Fluorouracil

Cerebellar dysfunction, inflammatory leukoencephalopathy, peripheral neuropathy, nausea, vomiting, severe diarrhoea and anorexia.

Irinotecan

Dysarthria, peripheral sensory neuropathy, palmar-plant erythrodysthesia, nausea, vomiting, severe diarrhoea, constipation and anorexia.